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Central Nervous System Reactions to Histamine-2 Receptor Blockers Ann Int Med 114:1027-1034, Cantu,T.G.&Korck,J.S., 1991 See this aricle in Pubmed Article Abstract Central nervous system toxicities have been associated with all H2 blockers.These rections generally occur during the first 2 weeks of therapy and resolve within 3 days of drug withdrawal.The estimated incidence of central nervous system reactions is 0.2%or less in outpatients and 1.6%to 80%in hospitalized patients.Cimetidine is most frequently associated with these reactions;however,no clear evidence exists that one H2 blocker is more likely than another to cause a reaction.Risk factors for central nervous system reactions have been proposed,but only advanced age has some,albeit limited,data to support it as a risk factor.Studies have only infrequently established causality and there have been difficulties in establishing risk factors for and relative incidences of a phenomenon that occurs infrequently in outpatients and that can be multifactorial in origin.Conclusions:All H2 blockers are associated with central nervous system reactions.There is no clear evidence of a higher rate of reactions with one H2 blocker compared with another.

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(click to filter results - removes previous filter) adverse drug reaction agitation cimetidine confusion delirium disorientation famotidine hallucination histamine-2 receptor blockers mental status,abnormal old age,neurology of psychosis psychosis,acute ranitidine review article somnolence

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